Ulk4 regulates GABAergic signaling and anxiety-related behavior
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چکیده
منابع مشابه
GABAergic Control of Critical Developmental Periods for Anxiety- and Depression-Related Behavior in Mice
Vulnerability for anxiety and depressive disorders is thought to have origins in early life and is increasingly recognized to involve deficits in GABAergic neurotransmission. Mice that were rendered heterozygous for the γ2 subunit gene of GABA(A) receptors (GABA(A)Rs) show behavioral, cognitive, neuroendocrine and pharmacologic features expected of a mouse model of melancholic anxious depressio...
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The Caenorhabditis elegans defecation motor program (DMP) is a highly coordinated rhythmic behavior that requires two GABAergic neurons that synapse onto the enteric muscles. One class of DMP mutants, called anterior body wall muscle contraction and expulsion defective (aex) mutants, exhibits similar defects to those caused by the loss of these two neurons. Here, we demonstrate that aex-2 encod...
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Symptoms of depression can be induced in humans through blockade of acetylcholinesterase (AChE) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ACh) receptors. Thus, ACh signaling could contribute to the etiology of mood regulation. To test this hypothesis, we administered the AChE inhibitor physostigmine to mi...
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Introduction Anxiety disorder is the most common psychiatric disorder in the world [1]. Hence, scientists today focus more on improving anxiety disorders in clinical and/or laboratory settings. It should be noted that many regions of brain regulate anxiety related behaviors which include limbic system, prefrontal cortex and amygdala. The important role of septum and hippocampus in controlling a...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2018
ISSN: 2158-3188
DOI: 10.1038/s41398-017-0091-5